# Investigation of the synthesis, gelation potential, and drug-loading capacities of two novel amides

## TL;DR

This paper describes the creation and testing of two new biocompatible amides as organogelators for drug delivery, focusing on their gelation and drug-loading abilities.

## Contribution

The synthesis and characterization of two novel amides with potential for drug delivery via skin application.

## Key findings

- The amides showed gelation potential with fatty acid esters and organic solvents.
- The gels demonstrated thermal stability and drug-loading capacities for ibuprofen and naproxen.
- SEM analysis confirmed the formation of a network during gelation.

## Abstract

This study consists of four steps. In the first, two different biocompatible organogelators were synthesized, starting with the L-isoleucine amino acid to obtain amide compounds. In the second step, the gelation potential of synthesized organogelators with fatty acid esters and organic solvents was investigated. These esters were chosen as gelation liquids due to their biocompatibility and also their penetration-enhancing properties when the drug is administered via the skin. After the minimum gel concentrations (MGCs) of the organogelators were determined, the melting point of gel T
g was found, and then, ΔH
g gelation enthalpy values were found by means of the Van’t Hoff equation. In addition to the gelation abilities and capacities of the organogelators being thus synthesized, their thermal stabilities were also determined. In the third stage of the study, the network which occurred during the formation of the gels was screened by an SEM device, and their characterizations were determined. In the study's fourth stage, the gels were loaded with ibuprofen and naproxen—known for their non-steroidal anti-inflammatory and analgesic effects—and their drug-loading capacities were thus determined.