# Outcomes of High-Dose Inhaled Nitric Oxide and Oxygen Administration for Severe Pulmonary Hypertension With Bronchopulmonary Dysplasia

## TL;DR

This case report examines the outcomes of using high-dose inhaled nitric oxide and oxygen to treat severe pulmonary hypertension in a premature infant with bronchopulmonary dysplasia.

## Contribution

The study highlights the potential ineffectiveness of oxygen and high-dose iNO in preventing PH deterioration in BPD.

## Key findings

- High-dose inhaled nitric oxide did not prevent severe PH in a BPD patient.
- Oxygen therapy was less effective in preventing PH deterioration.
- The patient could not survive despite the treatment.

## Abstract

Pulmonary hypertension (PH) with bronchopulmonary dysplasia (BPD) is fraught with high infant mortality rates. However, the intervention strategy for severe PH is unclear. This case report discusses the utility of long-term high-dose inhaled nitric oxide (iNO) administration and that of oxygen therapy for the prevention of PH deterioration.

A male infant weighing 864 g was delivered at a gestational age of 24 weeks and three days. The patient who had severe BPD was diagnosed with PH at a corrected gestational age (CGA) of 43 weeks. Although oxygen was administered to prevent PH, the patient still developed severe PH. Despite long-term high-dose (iNO) administration, the patient could not survive. The abovementioned treatment may exacerbate PH, and oxygen administration is less effective for the prevention of PH deterioration with BPD.