# SERa-Positive Oocyte Intracytoplasmic Injection and Its Outcome: A Case Report

## TL;DR

This case report shows how using special oocytes and adding a growth factor improved fertility treatment success for a woman with infertility.

## Contribution

The novel approach combines SERa+ oocytes with GM-CSF supplementation in ICSI to improve fertilization and pregnancy outcomes.

## Key findings

- The use of SERa+ oocytes with GM-CSF led to successful fertilization and embryo development.
- The patient achieved a twin pregnancy and delivered healthy babies.
- This individualized ART approach improved reproductive outcomes in a case of primary infertility.

## Abstract

This case report describes the use of smooth endoplasmic reticulum aggregates-positive (SERa+) oocytes along with intracytoplasmic sperm injection (ICSI), supplemented with granulocyte-macrophage colony-stimulating factor (GM-CSF), aiming to enhance fertilization rates and reproductive outcomes. A 39-year-old woman, facing primary infertility for the past seven years, received assisted reproductive treatment (ART), which included adding GM-CSF to the culture medium and culture SERa+ oocytes before ICSI. Clinical results, embryo quality, fertilization rates, and other fertility parameters were used to track the patient's progress toward this individualized approach that led to a positive twin pregnancy and healthy twin babies.