# Serum levels of stem cell factor for predicting embryo quality

## TL;DR

This study explores how serum stem cell factor levels before ovulation might predict the quality of embryos in women with mild endometriosis.

## Contribution

The study identifies a novel correlation between serum SCF levels and embryo quality in mild endometriosis patients.

## Key findings

- Serum SCF levels on the 8th day of stimulation differed significantly between TQ and non-TQ blastocyst groups in mild endometriosis patients.
- SCF levels on oocyte retrieval day also showed significant differences between TQ and non-TQ groups.
- The correlation suggests SCF could be a potential biomarker for embryo quality prediction in mild endometriosis.

## Abstract

We evaluated whether serum stem cell factor (s-SCF) levels just prior to ovulation induction could indicate the ability to develop a top-quality (TQ) blastocyst by day 5. We investigated patients with normal ovarian reserve (NOR), polycystic ovary syndrome (PCOS), diminished ovarian reserve (DOR), or mild endometriosis. Our pilot research suggests a correlation between s-SCF levels and the ability to form TQ blastocysts in patients with mild endometriosis. This significant statistical difference (p < 0.05) was noted between mild endometriosis patients for whom a TQ blastocyst was obtained and those for whom it was not possible, as measured on the 8th day of stimulation and the day of oocyte retrieval. The mean SCF levels in the serum of these women on the 8th day were at 28.07 (± 2.67) pg/ml for the TQ subgroup and 53.32 (± 16.02) pg/ml for the non-TQ subgroup (p < 0.05). On oocyte retrieval day it was 33.47 (± 3.93) pg/ml and 52.23 (± 9.72) pg/ml (p < 0.05), respectively.