# Comparison of 2D and 3D oxygen-enhanced MRI of the placenta

## TL;DR

This study compares 2D and 3D MRI techniques for measuring oxygen levels in the placenta and finds that 3D methods can capture full volume data without significant differences in oxygenation measurements.

## Contribution

The study demonstrates the feasibility of full-volume 3D oxygen-enhanced MRI in the placenta of healthy pregnancies.

## Key findings

- 3D OE-MRI can capture full placental volume without significant differences in ΔR1 compared to 2D methods.
- Baseline T1 values were significantly higher in 2D slices compared to 3D volumes.
- 3D data revealed sensitivity to ΔR1 changes in the intermediate placental space.

## Abstract

Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) of the human placenta is potentially a sensitive marker of in vivo oxygenation. This methodological study shows that full coverage of the placenta is possible using 3D mapping of the change in longitudinal relaxation rate (ΔR1), in a group of healthy pregnant subjects breathing elevated levels of oxygen. Twelve pregnant subjects underwent a comparison of 2D and 3D OE-MRI. ΔR1 was mapped for a single 2D slice (ss-2D), a single matched-slice from the 3D volume (ss-3D) and the full 3D volume (vol-3D). The group-average median ΔR1 values for ss-3D (0.023 s-1) and vol-3D (0.022 s-1) do not differ significantly from ss-2D (0.020 s-1), when compared using a two-tailed paired t-test (ss-3D (p = 0.58) and vol-3D (p = 0.70)). However, median baseline T1 (T1b) for ss-2D was higher (1603 ms) than T1b for ss-3D (1540 ms, p = 0.07) and significantly higher than vol-3D (1515 ms, p = 0.02), when compared using a two-tailed paired t-test. In contrast with previous studies, no correlation of median ΔR1 with gestation age at scan for the normal group (N = 10) was observed for ss-2D, likely due to the smaller gestational range. Full volume OE-MRI maps reveal sensitivity to changes in ΔR1, with some participants showing an enhanced gradient in the intermediate space between the fetal and maternal sides of the placenta in the 3D data. This study shows that it is feasible to acquire whole placental volume OE-MRI data in women with healthy pregnancy.