# Bortezomib-Induced Superficial Vasculitis in a Kidney Transplant Recipient: A Rare Case

**Authors:** Manish Balwani, Amit Pasari, Prasad Gurjar, Kapil Sejpal, Charulata Bawankule, Priyanka Tolani, Shubham Dubey, Pranjal Kashiv, Amol Bhawane, Sunny Malde, Sushrut Gupta

PMC · DOI: 10.7759/cureus.58743 · Cureus · 2024-04-22

## TL;DR

A kidney transplant patient developed a rare skin reaction after receiving bortezomib, which resolved after reducing the drug dose.

## Contribution

This case report highlights a rare adverse effect of bortezomib in kidney transplant recipients.

## Key findings

- A 30-year-old kidney transplant recipient developed superficial vasculitis after bortezomib administration.
- The inflammation resolved spontaneously after three weeks and a dose reduction.
- Nephrologists should be aware of potential cutaneous adverse effects of bortezomib.

## Abstract

Bortezomib is a frequently administered immunosuppressive agent in kidney transplantation. A 30-year-old male kidney transplant recipient developed an atypical reaction on the left hand in terms of spider-like extensions, indicating erythematous inflammation along the superficial veins after bortezomib intravenous administration. The inflammation spontaneously resolved after three weeks with a bortezomib dose reduction. Nephrologists must be familiar with the potential cutaneous bortezomib-induced adverse effects.

## Linked entities

- **Chemicals:** bortezomib (PubChem CID 387447)

## Full-text entities

- **Diseases:** erythematous inflammation (MESH:D007249), Vasculitis (MESH:D014657)
- **Chemicals:** Bortezomib (MESH:D000069286)

## Full text

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## Figures

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## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC11110920/full.md

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Source: https://tomesphere.com/paper/PMC11110920