Immunoglobulin A Vasculitis After Initiation of Treatment for Tuberculous Pleurisy: A Case Report and Literature Review

TL;DR

An 86-year-old man developed IgAV after starting treatment for tuberculosis, suggesting anti-tuberculous drugs may trigger the condition.

Contribution

This case report adds to the evidence that anti-tuberculous drugs can cause IgAV.

Findings

IgAV developed in a patient after initiating anti-tuberculosis treatment for pleurisy.

Few case reports link anti-tuberculous drugs to IgAV, making this case noteworthy.

The report emphasizes the need to consider drug-induced IgAV in tuberculosis patients.

Abstract

Immunoglobulin A vasculitis (IgAV), also known as Henoch-Schönlein purpura (HSP), is a disease that causes inflammation and bleeding in small blood vessels in the skin, joints, intestines, and kidneys. Although various infections and chemicals are known to be triggers, the underlying cause of IgAV remains unknown. Here, we describe a case of an 86-year-old male patient with IgAV that developed after anti-tuberculosis treatment for tuberculous pleurisy. There have been several case reports implicating Mycobacterium tuberculosis and other acid-fast bacterium in the development of IgAV, but only a few case reports implicating anti-tuberculous drugs. This case highlights the importance of recognizing that IgAV can be caused by anti-tuberculous drugs.

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