# Ciliary Functional Analysis in Chronic Rhinosinusitis with Polyps after Multimodal Intervention: Oral Corticosteroid, Functional Endoscopic Sinus Surgery, and Omalizumab Injection

## TL;DR

A woman with chronic nasal polyps underwent multiple treatments, and ciliary function improved most with omalizumab injections.

## Contribution

First study to investigate ciliary function using DHSV in a patient treated with omalizumab.

## Key findings

- Omalizumab injections significantly improved ciliary beat pattern and frequency.
- Oral corticosteroids showed only partial improvement in ciliary function.
- Omalizumab reduced the patient's SNOT-22 score, indicating better symptom control.

## Abstract

In her late 50 s, a woman with a medical history of endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) experienced a relapse of nasal polyps, significantly impacting her breathing and sense of smell. She underwent a multifaceted treatment approach, including oral corticosteroids, functional endoscopic sinus surgery, and omalizumab injections. Digital high-speed videomicroscopy (DHSV) revealed only partial improvement in ciliary beat pattern and ciliary beat frequency with oral corticosteroid treatment, while significant improvement in these ciliary parameters was observed with omalizumab injections. Furthermore, administration of omalizumab resulted in a decrease in her SNOT-22 (Sinonasal Outcome Test 22) score. Notably, this case report represents the first study investigating ciliary function using DHSV in a patient treated with omalizumab.