# The Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA), Associated with Renal Compromise and Cutaneous Calcinosis: A Case Report and Literature Review

## TL;DR

This paper presents a case of ASIA with unique symptoms like kidney disease and skin calcinosis, highlighting the importance of recognizing this autoimmune condition.

## Contribution

The paper contributes a detailed case report with unique clinical features of ASIA, expanding its known symptomatology.

## Key findings

- The case exhibited advanced chronic kidney disease and hypercalcemia with suppressed PTH.
- Bilateral nephrocalcinosis and cutaneous calcinosis were observed alongside positive autoantibodies.
- The case emphasizes the variability and complexity of ASIA's clinical manifestations.

## Abstract

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 to provide a more precise syndromic characterization of clinical manifestations observed in patients exposed to adjuvant substances such as biopolymers and silicone, among others. The clinical spectrum of this entity is variable, ranging from local involvement to potentially fatal immune-mediated systemic involvement. The interest in ASIA has grown in recent years, reinforcing diagnostic criteria and deepening the understanding of its pathophysiological behavior. This case report highlights a distinct range of clinical symptoms, such as general symptoms, advanced-stage chronic kidney disease, persistent hypercalcemia with suppressed parathyroid hormone (PTH), bilateral nephrocalcinosis, cutaneous calcinosis, and the presence of positive autoantibodies, emphasizing the significance of understanding this condition.