# The Network between Heart and Liver from the View of Persian Medicine Versus Conventional Medicine

## TL;DR

This paper compares how Persian and conventional medicine view the connection between the heart and liver, finding that both approaches align in identifying shared disease causes.

## Contribution

It bridges Persian medicine's material causes with conventional network medicine to map heart-liver interactions.

## Key findings

- Persian medicine's disease definitions align with conventional genes and metabolites between heart and liver.
- Network analysis revealed shared causes of diseases between the two organs.
- The study highlights the potential for better disease prediction and treatment using this integrated approach.

## Abstract

Background: Liver and heart are two important organs in the human body, whose
function strongly affects other organs. On the other hand, these two main organs
affect each other due to common metabolic pathways. Therefore, a disorder in any
of them can lead to disease in other organs. Today, using the network medicine
perspective, these complex connections can be easily mapped and discovered. From
the Persian medicine viewpoint, links are formed based on the material causes of
diseases, while from the conventional medicine viewpoint, they are mostly formed
due to metabolites, genes, and pathways. Materials and Methods: In this article,
we first investigated the recent articles of conventional medicine that examine
the relationship between heart and liver in the important databases. Then, we
checked out the sources of Persian medicine and finally, using the RStudio
software used in network medicine for text mining, we drew the communication
network centered on heart and liver and their mutual causes from the perspective
of Persian Medicine. Results: Examining the network connection between the heart
and the liver showed that the definitions based on Persian medicine, which are
based on the material causes of diseases, are very compatible with the genes,
metabolites and pathways between these two organs. Conclusion: Understanding
these concepts can be helpful in detecting the co-occurrence of diseases of
these two organs, as well as predicting the possible occurrence of related
diseases between the heart and liver, and ultimately in better treatment.