# Co-infectious Uveitis With Syphilis and Lyme Disease: A Case Report

## TL;DR

This case report describes a rare instance of uveitis caused by both syphilis and Lyme disease, highlighting the importance of timely diagnosis to prevent vision loss.

## Contribution

The novelty lies in the co-occurrence of syphilis and Lyme disease as causes of uveitis, which is a rare and underreported clinical scenario.

## Key findings

- Uveitis can result from co-infection with syphilis and Lyme disease.
- Prompt diagnosis and treatment are crucial to prevent permanent vision loss.
- Ophthalmic symptoms such as blurred vision and eye pain may indicate underlying infectious uveitis.

## Abstract

Uveitis is the inflammation of the uveal tract (i.e., iris, ciliary body, and choroid). Uveitis is categorized into the following three types based on the anatomical location of inflammation: anterior, intermediate, and posterior uveitis. Severe cases may lead to panuveitis, where all three layers may become inflamed potentially resulting in permanent vision loss. Uveitis can arise from different underlying disorders, including infectious causes or autoimmune disorders. Syphilis and Lyme disease are uncommon causes of uveitis. Eye involvement can occur at any stage in Lyme disease, characterized by diverse manifestations such as conjunctivitis, episcleritis, keratitis, uveitis, neuroretinitis, and retinal vasculitis. Patients may present with symptoms of blurred vision, eye pain or discomfort, visual floaters, headache, or intolerance to light. Patients can risk vision loss if not diagnosed and treated promptly.