# Papillary Neoplasms of the Gallbladder and Extrahepatic Bile Ducts: A Report of Two Cases With Associated Invasive Carcinoma

## TL;DR

This paper reports two rare cases of gallbladder and bile duct tumors that were linked to invasive cancer, emphasizing the need for detailed microscopic analysis.

## Contribution

The paper contributes two rare clinical cases linking papillary neoplasms to invasive carcinoma, highlighting diagnostic challenges.

## Key findings

- A 63-year-old male had ICPN with invasive carcinoma in the gallbladder.
- A 65-year-old female had IPNB with invasive carcinoma in the common bile duct.
- Thorough histological examination is critical for identifying associated invasive cancer in these rare lesions.

## Abstract

Intracholecystic papillary neoplasm (ICPN) of the gallbladder is a macroscopically visible premalignant lesion protruding into the gallbladder lumen, with infrequent association with invasive adenocarcinoma. Intraductal papillary neoplasm of the bile ducts (IPNB) is a non-invasive lesion characterized by intraductal papillary or villous architecture. Both ICPN and IPNB are rare findings in the gallbladder and biliary tract pathology. Diagnosis relies on clinical manifestations, imaging techniques, and comprehensive histological examination. Here, we present two cases: a 63-year-old male with mild abdominal pain found to have a gallbladder mass, diagnosed histologically as ICPN with associated invasive carcinoma; and a 65-year-old female with chronic jaundice and a large tumor mass in the common bile duct, histologically diagnosed as IPNB with associated invasive carcinoma. These cases highlight the importance of a careful and thorough microscopic examination to rule out differential diagnoses and to reveal any potential invasive carcinoma associated with these uncommon lesions.