# Spontaneous remission of choroidal involvement by chronic myelomonocytic leukemia: a case report

## TL;DR

A woman with chronic myelomonocytic leukemia experienced spontaneous regression of a choroidal lesion without intensive treatment.

## Contribution

This case highlights that a 'watch and wait' approach may be effective for isolated ocular lesions in CMML.

## Key findings

- The patient's choroidal lesion spontaneously regressed after biopsy.
- The patient remained stable with no ocular involvement after 1.5 years.
- A non-invasive follow-up strategy may be sufficient for isolated ocular lesions in CMML.

## Abstract

Chronic myelomonocytic leukemia (CMML) is a rare hematological disorder characterized by variable risk of evolution to acute myeloid leukemia; to date, allogeneic stem cell transplantation is the only curative treatment. We report a case of choroidal involvement in a woman affected by CMML and presenting only with visual impairment. The patient was initially evaluated for an intensive therapeutic approach, but after biopsy the ocular lesion spontaneously regressed. Thus a “watch and wait” strategy was preferred. One year and a half after initial diagnosis, the patient is alive, with stable hematological disease and without any ocular involvement. Therefore, a close, not invasive follow up could be useful to tailor treatment for patients affected by single ocular lesions in CMML.