# Peritumoral Clefts in Basal Cell Carcinoma: Matrix Metabolism and Primary Cilium

## TL;DR

This paper explores how structural changes in BCC cells may lead to the formation of peritumoral clefts, a common feature in basal cell carcinoma.

## Contribution

The paper proposes a novel hypothesis linking primary cilia structural changes to matrix alterations in BCC.

## Key findings

- Peritumoral clefts are a prominent feature in basal cell carcinoma.
- Structural changes in primary cilia may contribute to matrix alterations in BCC cells.
- Further research is needed to confirm the proposed mechanisms.

## Abstract

The phenomenon of tissue retraction, characterized by peritumoral spaces or clefts, is prominent in basal cell carcinoma (BCC) tumors, yet its underlying mechanisms remain unclear. Proposed factors include changes in cell structures, enzymatic activity, and alterations in the Hedgehog (Hh) signaling pathway. This article discusses these factors and proposes that structural changes in BCC cells' primary cilia may contribute to matrix alterations, leading to the formation of peritumoral clefts. Further research is needed to confirm these hypotheses and understand BCC's unique growth patterns.