# Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle

## TL;DR

The study shows that chromosomes stay on one side of the cell's axis during the cell cycle, avoiding crossing to the opposite side.

## Contribution

The novel finding is the ipsilateral restriction of chromosome movement relative to the centrosome and apical-basal axis.

## Key findings

- Centromere components form two clusters on either side of the centrosome and apical-basal axis.
- Centromeres oscillate within one cluster without crossing to the other.
- This suggests an axis-dependent restriction of chromosome movement during mitosis.

## Abstract

Little is known about how distance between homologous chromosomes are controlled during the cell cycle. Here, we show that the distribution of centromere components display two discrete clusters placed to either side of the centrosome and apical/basal axis from prophase to G1 interphase. 4-Dimensional live cell imaging analysis of centromere and centrosome tracking reveals that centromeres oscillate largely within one cluster, but do not cross over to the other cluster. We propose a model of an axis-dependent ipsilateral restriction of chromosome oscillations throughout mitosis.