Correction: Subdomains of the Helicobacter pylori Cag T4SS outer membrane core complex exhibit structural independence
Jacquelyn R Roberts, Sirena C Tran, Arwen E Frick-Cheng, Kaeli N Bryant, Chiamaka D Okoye, W Hayes McDonald, Timothy L Cover, Melanie D Ohi
TL;DR
This study shows that two major parts of a bacterial complex can function independently, which was not previously expected.
Contribution
The study reveals structural independence between the OMC and PR subdomains in H. pylori Cag T4SS.
Findings
Deletion mutants showed structural independence between the OMC and PR subdomains.
Proteomic analysis confirmed the independence of these subdomains.
The findings challenge previous assumptions about the complex's structure.
Abstract
Structural and proteomic analysis of H. pylori Cag T4SSs purified from deletion mutants highlight the unexpected structural independence between the OMC and PR, two major subdomains of this complex.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsMicrobial Metabolites in Food Biotechnology · Helicobacter pylori-related gastroenterology studies · Probiotics and Fermented Foods
Article: Roberts JR, Tran SC, Frick-Cheng AE, Bryant KN, Okoye CD, McDonald WH, Cover TL, Ohi MD (2024 April 17) Subdomains of the Helicobacter pylori Cag T4SS outer membrane core complex exhibit structural independence. Life Sci Alliance 7(6): e202302560. doi: 10.26508/lsa.202302560. PMID: 38631913.
In this manuscript, there was an error in the Data Availability section where the ∆cagT PR EM map was incorrectly uploaded and referenced as “EMD-42395.” The correct EM map has now been uploaded and the map has a new accession number, “EMD-44587.”
Supplementary Material
Reviewer comments