# Outcomes associated with planned place of birth among low-risk pregnancies in Ontario, Canada (2012–2021): A protocol for a population-based propensity score weighted cohort study

## TL;DR

This study aims to compare the safety of planned home births versus hospital births for low-risk pregnancies in Ontario, Canada, focusing on neonatal and maternal outcomes.

## Contribution

The study introduces a novel approach using propensity score weighting to reduce selection bias in analyzing planned place of birth outcomes.

## Key findings

- The study will assess neonatal morbidity and mortality outcomes across different planned birth settings.
- It will use multivariate analyses to compare maternal outcomes and birth interventions.
- Stratified analyses will consider parity and prior caesarean birth history.

## Abstract

Evidence suggests that for low-risk pregnancies, planned home births attended by a skilled health professional in settings where such services are well integrated are associated with lower risk of intrapartum interventions and no increase in adverse health outcomes. Monitoring and updating evidence on the safety of planned home births is necessary to inform ongoing clinical and policy decisions.

This protocol describes a population-based retrospective cohort study which aims to compare risk of (a) neonatal morbidity and mortality, and (b) maternal outcomes and birth interventions, between people at low obstetrical risk with a planned home birth with a midwife, a planned a hospital birth with a midwife, or a planned hospital birth with a physician. The study population will include Ontario residents who gave birth in Ontario, Canada between April 1, 2012, and March 31, 2021. We will use data collected prospectively in a provincial perinatal data registry. The primary outcome will be severe neonatal morbidity or mortality, a composite binary outcome that includes one or more of the following conditions: stillbirth during the intrapartum period, neonatal death (death of a liveborn infant in the first 28 completed days of life), five-minute Apgar score <4, or infant resuscitation requiring cardiac compressions. We will conduct a stratified analysis with three strata: nulliparous, parous—no previous caesarean birth, and parous—prior caesarean birth. To reduce the impact of selection bias in estimating the effect of planned place of birth on neonatal and maternal outcomes, we will use propensity score (PS) overlap weighting (OW) and modified Poisson regression to conduct multivariate analyses.