# Editorial: The therapeutic inhibition of macrophage checkpoints

**Authors:** Alexandre P. A. Theocharides, Gregor Hutter, Yasuyuki Saito

PMC · DOI: 10.3389/fimmu.2024.1418281 · 2024-04-26

## Full-text entities

- **Genes:** EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, MERTK (MER proto-oncogene, tyrosine kinase) [NCBI Gene 10461] {aka MER, RP38, Tyro12, c-Eyk, c-mer}, SIRPA (signal regulatory protein alpha) [NCBI Gene 140885] {aka BIT, CD172A, MFR, MYD-1, MYD1, P84}, SIRPB2 (signal regulatory protein beta 2) [NCBI Gene 284759] {aka PTPN1L, PTPNS1L3, dJ776F14.2}, PDCD1 (programmed cell death 1) [NCBI Gene 5133] {aka ADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2}, THBS1 (thrombospondin 1) [NCBI Gene 7057] {aka THBS, THBS-1, TSP, TSP-1, TSP1}, AXL (AXL receptor tyrosine kinase) [NCBI Gene 558] {aka ARK, AXL3, JTK11, Tyro7, UFO}, LILRB1 (leukocyte immunoglobulin like receptor B1) [NCBI Gene 10859] {aka CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7}, GGH (gamma-glutamyl hydrolase) [NCBI Gene 8836] {aka GATD10, GH}, CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, HLA-C (major histocompatibility complex, class I, C) [NCBI Gene 3107] {aka D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1}, SIGLEC9 (sialic acid binding Ig like lectin 9) [NCBI Gene 27180] {aka CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9}, ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, TYRO3 (TYRO3 protein tyrosine kinase) [NCBI Gene 7301] {aka BYK, Dtk, Etk-2, RSE, Rek, Sky}, CD47 (CD47 molecule) [NCBI Gene 961] {aka IAP, MER6, OA3}, SIGLEC10 (sialic acid binding Ig like lectin 10) [NCBI Gene 89790] {aka PRO940, SIGLEC-10, SLG2}, CD24 (CD24 molecule) [NCBI Gene 100133941] {aka CD24A}, TYROBP (transmembrane immune signaling adaptor TYROBP) [NCBI Gene 7305] {aka DAP12, KARAP, PLOSL, PLOSL1}
- **Diseases:** myelodysplastic syndrome (MESH:D009190), breast cancer (MESH:D001943), immunodeficient (MESH:D007153), pancreatic adenocarcinoma (MESH:D010190), B-cell lymphoma (MESH:D016393), liver metastasis (MESH:D009362), acute myeloid leukemia (MESH:D015470), Cancer (MESH:D009369), hematological malignancies (MESH:D019337)
- **Chemicals:** durvalumab (MESH:C000613593), rituximab (MESH:D000069283)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** HIS — Homo sapiens (Human), Transformed cell line (CVCL_WG26)

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Source: https://tomesphere.com/paper/PMC11088240