# Extraintestinal Manifestations of Inflammatory Bowel Disease: Unraveling Valvulopathy Connections

**Authors:** Akhaled Zaher

PMC · DOI: 10.7759/cureus.57996 · Cureus · 2024-04-10

## TL;DR

This paper explores the link between inflammatory bowel disease and heart valve problems, highlighting a case of a patient with ulcerative colitis and multiple valvular diseases.

## Contribution

The paper presents a case emphasizing the connection between IBD and valvular heart disease, suggesting inflammation's role in cardiovascular complications.

## Key findings

- IBD patients have an increased risk of cardiovascular disease compared to the general population.
- Valvular heart disease in IBD includes calcific aortic valve disease, mitral valve prolapse, and endocarditis.
- Chronic inflammation may contribute to the development of valvular abnormalities in IBD patients.

## Abstract

The clinical presentation of inflammatory bowel disease (IBD) includes both gastrointestinal manifestations and extraintestinal manifestations (EIM). Over the past years, a growing number of studies have indicated that patients suffering from IBD have an increased risk of developing cardiovascular disease. Although the precise prevalence of cardiac complications in IBD remains uncertain, emerging evidence suggests a heightened incidence compared to the general population. Valvular heart disease (VHD) in IBD encompasses calcific aortic valve disease, mitral valve prolapses, and endocarditis, potentially associated with chronic inflammation. Considering the role of inflammation in developing cardiovascular manifestations, the management should include preventing flares and maintaining remission for as long as possible. This case highlights the intricate interplay between IBD and cardiovascular complications, particularly valvular abnormalities. We present a 37-year-old male with a history of ulcerative colitis (UC) who was found to have multiple valvular diseases.

## Linked entities

- **Diseases:** inflammatory bowel disease (MONDO:0005265), ulcerative colitis (MONDO:0005101)

## Full-text entities

- **Diseases:** chronic inflammation (MESH:D007249), UC (MESH:D003093), VHD (MESH:D006349), IBD (MESH:D015212), gastrointestinal manifestations (MESH:D005767), cardiac complications (MESH:D006331), EIM (MESH:D012877), aortic valve disease (MESH:D000082862), endocarditis (MESH:D004696), cardiovascular complications (MESH:D002318), mitral valve prolapses (MESH:D008945)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11087212/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11087212/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC11087212/full.md

---
Source: https://tomesphere.com/paper/PMC11087212