# Treatment of a Patient with Acute Promyelocytic Leukemia with Multiple Isolated Relapses in the Central Nervous System: A Case Report and Mini-Review of the Literature

## TL;DR

This paper reports a rare case of acute promyelocytic leukemia with multiple central nervous system relapses and summarizes treatment approaches.

## Contribution

The paper presents a unique case and literature review on managing APL relapses in the CNS, where guidelines are lacking.

## Key findings

- A patient with APL experienced multiple isolated CNS relapses.
- Current literature and treatment options for CNS relapse in APL are summarized.
- No consensus exists for managing CNS relapse in APL.

## Abstract

The efficacy of therapeutics for acute promyelocytic leukemia (APL) has exhibited an increase in recent years. Only a few patients experience relapse, including extramedullary relapse, and in patients with extramedullary relapse, the central nervous system (CNS) is the most common site. To date, there is no expert consensus or clinical guidelines available for CNS relapse, at least to the best of our knowledge. The optimal therapeutic strategy and management options for these patients remain unclear. The present study reports the treatment of a patient with APL with multiple isolated relapses in the CNS. In addition, through a mini-review of the literature, the present study provides a summary of various reports of this disease and discusses possible treatment options for these patients.