# Recent Advances in the Nickel-Catalyzed Alkylation of C-H Bonds

## TL;DR

This paper reviews recent progress in using nickel to catalyze the alkylation of C-H bonds, offering a more sustainable and cost-effective alternative to traditional methods.

## Contribution

The paper provides a focused review on nickel-catalyzed C-H bond alkylation using alkyl halides and olefins.

## Key findings

- Nickel catalysis enables efficient C-H bond alkylation with alkyl halides.
- Olefins can also serve as effective alkyl sources in nickel-catalyzed reactions.
- First-row transition metals like nickel offer advantages over second-row metals in terms of cost and sustainability.

## Abstract

Functionalization of C-H bonds has emerged as a powerful strategy for converting inert, nonfunctional C-H bonds into their reactive counterparts. A wide range of C-H bond functionalization reactions has become possible by the catalysis of metals, typically from the second row of transition metals. First-row transition metals can also catalyze C-H functionalization, and they have the merits of greater earth-abundance, lower cost and better environmental friendliness in comparison to their second-row counterparts. C-H bond alkylation is a particularly important C-H functionalization reaction due to its chemical significance and its applications in natural product synthesis. This review covers Ni-catalyzed C-H bond alkylation reactions using alkyl halides and olefins as alkyl sources.