# Two Cases of Painful Thyroiditis With Subsequent Hypothyroidism Following Cord Blood Transplant

## TL;DR

Two patients developed painful thyroiditis followed by hypothyroidism about 100 days after cord blood transplant, highlighting the need for thyroid monitoring in such cases.

## Contribution

Reports two rare clinical cases linking cord blood transplantation to painful thyroiditis and subsequent hypothyroidism.

## Key findings

- Painful thyroiditis occurred approximately 100 days after cord blood transplant in two patients.
- Both patients later developed hypothyroidism requiring treatment.
- Thyroid monitoring is recommended for patients with post-transplant neck pain.

## Abstract

We report two rare cases of painful thyroiditis approximately 100 days after unrelated cord blood transplantation (CBT), which progressed to hypothyroidism. Patient one, a 45-year-old woman, developed goiter, tenderness, and thyrotoxicity on day 100 after CBT for relapsed acute lymphocytic leukemia. Scintigraphy suggested destructive thyroiditis; symptoms improved with one-month beta-blocker and prednisolone treatment. Two months later, hypothyroidism developed which required supplementation-based treatment. Patient two, a 49-year-old man, developed goiter, tenderness, and thyrotoxicosis on day 96 after CBT for acute myelogenous leukemia. Hypothyroidism developed after nonsteroidal anti-inflammatory drug treatment. Thyroiditis and hypothyroidism should be considered in patients who develop neck pain after CBT.