# Exploration and practice of novel models of cellular therapy and hematopoietic stem cell transplantation

## TL;DR

This paper explores new approaches combining cellular therapy and hematopoietic stem cell transplantation for treating blood diseases.

## Contribution

The paper introduces novel therapeutic models integrating CAR-T cell therapy with stem cell transplantation.

## Key findings

- Cellular therapy shows promise in treating refractory B-cell malignancies.
- Combining cell therapy with stem cell transplantation may improve patient outcomes.
- CAR-T therapy demonstrates unique advantages in treating blood tumors and transplant complications.

## Abstract

造血干细胞移植为多种血液学疾病尤其是恶性血液病提供了有效治愈办法，其治疗体系不断优化，供者来源不断扩大，适应证不断拓展，疗效也在一定程度上取得了突破。目前造血干细胞移植技术在大部分血液病中的地位仍不可撼动，但是原发病复发及造血干细胞移植相关并发症仍是影响患者长期生存及生活质量的两大临床困境。以嵌合抗原受体T（CAR-T）细胞治疗为代表的细胞治疗在难治/复发B细胞恶性肿瘤的治疗上取得了突破性进展。细胞治疗相比传统药物具有独特的体内代谢动力学特点，依靠免疫特异性识别及干细胞的修复能力，目前在血液肿瘤治疗及移植并发症处理中崭露头角，目前多项临床研究已经初步展现了细胞治疗与造血干细胞移植结合的新诊疗模式。