# A Case of Recurrent Sputum-Positive Pulmonary Tuberculosis Presenting With Pulmonary Mycetoma

**Authors:** Adinath Gaikwad, Pankaj Wagh, Souvik Sarkar, Mansi Khare

PMC · DOI: 10.7759/cureus.57757 · Cureus · 2024-04-07

## TL;DR

This case study presents a rare instance of a tuberculosis patient who also developed pulmonary mycetoma, highlighting the importance of accurate diagnosis to avoid severe health outcomes.

## Contribution

The paper highlights a rare co-infection of tuberculosis and mycetoma, emphasizing the need for differential diagnosis to prevent mismanagement.

## Key findings

- The patient's failure to continue anti-tubercular medication led to disease recurrence.
- Combination therapy with anti-tubercular drugs and itraconazole was initiated.
- Surgical excision is recommended over pharmacotherapy for mycetoma in tuberculosis patients.

## Abstract

Pulmonary tuberculosis is a notorious disease as it can cause severe morbidity and mortality. In this case, we discuss a 75-year-old male tuberculosis patient from a rural area with no underlying comorbidities who failed to continue anti-tubercular medication after two months. The case discusses the diagnostic modalities confirming the diagnosis, sputum culture for Mycobacterium tuberculosis, imaging studies, including X-ray and CT of the chest, and laboratory parameters for identifying pulmonary mycetoma. The patient is now on anti-tubercular therapy (isoniazid, rifampicin, pyrazinamide, and ethambutol combination) and the anti-fungal drug itraconazole. Though pharmacotherapy for the treatment of mycetoma in patients with tuberculosis has a minimal role, the more appropriate treatment is surgical excision via lobectomy. As the occurrence of tuberculosis and mycetoma is a rare phenomenon, it is essential to rule out aspergillosis as both have similar presenting symptoms. Diagnosis of this co-infection can be the crucial difference between morbidity and mortality.

## Linked entities

- **Chemicals:** isoniazid (PubChem CID 3767), rifampicin (PubChem CID 135398735), pyrazinamide (PubChem CID 1046), ethambutol (PubChem CID 14052), itraconazole (PubChem CID 55283)
- **Diseases:** tuberculosis (MONDO:0018076)

## Full-text entities

- **Diseases:** Pulmonary Tuberculosis (MESH:D014397), Pulmonary Mycetoma (MESH:D008271), aspergillosis (MESH:D001228), tuberculosis (MESH:D014376)
- **Chemicals:** itraconazole (MESH:D017964), isoniazid (MESH:D007538), rifampicin (MESH:D012293), pyrazinamide (MESH:D011718), ethambutol (MESH:D004977)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mycobacterium tuberculosis (species) [taxon 1773]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11075578/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC11075578/full.md

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Source: https://tomesphere.com/paper/PMC11075578