# Vaginal leiomyoma in a goat expressing the nuclear progesterone receptor (PGR): a case report

## TL;DR

A seven-year-old goat with a vaginal tumor was found to have a leiomyoma expressing a progesterone receptor, suggesting potential hormonal influences on the tumor.

## Contribution

This case report is the first to document a vaginal leiomyoma in a goat with nuclear progesterone receptor expression.

## Key findings

- A vaginal tumor in a goat was identified as a leiomyoma through histopathological examination.
- The tumor tissue expressed the nuclear progesterone receptor (PGR), indicating potential hormonal responsiveness.
- The goat showed no recurrence of symptoms one year after successful tumor removal.

## Abstract

The risk of developing tumorous diseases in the genital tract also increases with age in animals. One of the classified tumor types is genital leiomyoma. Presently, our understanding of the pathogenesis of this tumor in goats is, however, limited. This accounts also for the information regarding the presence of steroid hormone receptors and, thus, possible responsiveness to circulating steroids.

This study describes the case of a vaginal tumor in a seven-year-old Anglo-Nubian goat. The goat was presented due to blood mixed vaginal discharge. Per vaginal examination a singular pedunculated mass in the dorsum of the vagina measuring approximately 3 cm x 4 cm x 4 cm was revealed. After administering epidural anesthesia, the mass was removed electrothermally. There were no postoperative complications. The histopathological examination identified the mass as a leiomyoma. The immunohistochemical examination revealed the presence of the nuclear progesterone receptor (PGR) in the tumor tissue. One year after the surgery, during the follow-up examination, the goat was in good overall health, and the owners had not observed any recurrence of vaginal discharge.

When observing vaginal discharge in goats, it is important to consider the possibility of genital tract tumors. These tumors may express sex steroid receptors. In the future, it is worth considering the investigation of potential approaches for preventing tumorigenesis or treating the tumor, such as castration or the administration of antiprogestogens.