# PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma

## TL;DR

This study shows that PDZK1 is linked to MRI perfusion features and poor outcomes in high-grade glioma patients.

## Contribution

The study identifies PDZK1 as a novel biomarker correlated with DCE-MRI parameters and survival in HGG.

## Key findings

- PDZK1 expression is positively correlated with Ktrans 90 and ve_90 in HGG patients.
- High PDZK1 levels are associated with poor overall and progression-free survival in HGG.
- PDZK1 helps differentiate between grade III and IV high-grade gliomas.

## Abstract

•PDZK1 is up-regulated in cancer tissues of HGG patients.•PDZK1 expression was significantly positively correlated with ktrans
90, ve_90.•PDZK1 expression was negatively correlated with kep_max, kep_90.•Patients with high PDZK1 expression had poor OS and PFS.

PDZK1 is up-regulated in cancer tissues of HGG patients.

PDZK1 expression was significantly positively correlated with ktrans
90, ve_90.

PDZK1 expression was negatively correlated with kep_max, kep_90.

Patients with high PDZK1 expression had poor OS and PFS.

This study investigated the relationship between PDZK1 expression and Dynamic Contrast-Enhanced MRI (DCE-MRI) perfusion parameters in High-Grade Glioma (HGG).

Preoperative DCE-MRI scanning was performed on 80 patients with HGG to obtain DCE perfusion transfer coefficient (Ktrans), vascular plasma volume fraction (vp), extracellular volume fraction (ve), and reverse transfer constant (kep). PDZK1 in HGG patients was detected, and its correlation with DCE-MRI perfusion parameters was assessed by the Pearson method. An analysis of Cox regression was performed to determine the risk factors affecting survival, while Kaplan-Meier and log-rank tests to evaluate PDZK1′s prognostic significance, and ROC curve analysis to assess its diagnostic value.

PDZK1 was upregulated in HGG patients and predicted poor overall survival and progression-free survival. Moreover, PDZK1 expression distinguished grade III from grade IV HGG. PDZK1 expression was positively correlated with Ktrans 90, and ve_90, and negatively correlated with kep_max, and kep_90.

PDZK1 is upregulated in HGG, predicts poor survival, and differentiates tumor grading in HGG patients. PDZK1 expression is correlated with DCE-MRI perfusion parameters.