# Evaluation of CoVid-19 infection among vaccinated and unvaccinated individuals using biochemical markers

**Authors:** Allavarapu Ramya Sree, K Sethumadhavan, S.P. Tejaswi Pullakanam, Purimitla Usharani

PMC · DOI: 10.6026/973206300200223 · Bioinformation · 2024-03-31

## TL;DR

This study compares CoVid-19 infection severity and symptoms between vaccinated and unvaccinated individuals using biochemical markers.

## Contribution

The study provides new insights into how vaccination affects symptom profiles and infection severity in CoVid-19 patients.

## Key findings

- Vaccinated individuals showed milder symptoms like fatigue and hair loss compared to unvaccinated individuals who experienced weakness in limbs.
- No deaths were reported among vaccinated individuals, while the unvaccinated group experienced severe infections and some deaths.
- The second wave of CoVid-19 saw the highest number of cases, with the 31-40 age group being the most affected.

## Abstract

The evaluation of infection rate for CoVid-19 cases among vaccinated and unvaccinated individuals using haematological parameters is
of interest. Data such as age, gender, occupation, location, signs and symptoms, length of symptoms, date of sample collection and
report generation, status of vaccinations, and outcome available in the database was used in this analysis. Ferritin levels, D-dimer
values, CRP, troponin-1 levels and platelet count of each CoVid-19 patient were recorded and analysed. Data shows that maximum number of
cases was reported during the second wave 143 (51.07%). The common age group affected was 31-40 years 28.56%. The common symptom
identified was weakness in arms and legs among the unvaccinated group of CoVid-19 positive group. However, common symptom identified was
fatigue (87%) among those who received only the first dose of CoVid vaccine. Nonetheless, the symptom identified was hair loss (68%)
among those who received both the doses of CoVid vaccine. Thus, data shows that people do experience severe and life-threatening
COVID-19 infection despite receiving the vaccination. Nonetheless, the infection is mild and very few individuals require hospitalization.
No deaths are reported in the group that received the vaccination. This is in contrast to the unvaccinated group, which had a severe
CoVid-19 infection with few deaths reported.

## Linked entities

- **Diseases:** CoVid-19 (MONDO:0100096)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** COVID-19 infection (MESH:D000086382), weakness in arms and legs (MESH:D018908), hair loss (MESH:D000505), deaths (MESH:D003643), fatigue (MESH:D005221), infection (MESH:D007239)
- **Chemicals:** CoVid (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC11069607/full.md

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Source: https://tomesphere.com/paper/PMC11069607