# Lower Limb Deep Venous Thrombosis After Posterior Spinal Fusion as an Initial Manifestation of Factor V Leiden Mutation in a Pediatric Patient: A Case Report

**Authors:** Cristian J Cortes-Nieves, Nicole Ramirez, Aracelis Nieves, Norman Ramírez

PMC · DOI: 10.7759/cureus.57543 · 2024-04-03

## TL;DR

A 12-year-old girl developed a blood clot after spinal surgery due to an undiagnosed genetic condition, highlighting the need for awareness in pediatric cases.

## Contribution

This case report highlights Factor V Leiden mutation as a rare cause of DVT in pediatric spinal surgery patients with no prior history.

## Key findings

- A pediatric patient developed DVT after spinal fusion due to an underlying Factor V Leiden mutation.
- The patient had no prior thrombotic events or family history of clotting disorders.
- The case emphasizes the importance of screening for genetic clotting disorders in at-risk pediatric surgical patients.

## Abstract

Deep venous thrombosis (DVT) is a serious condition in which a blood clot forms in a deep vein, usually of the lower extremity. In pediatric orthopedic surgery, the incidence of thrombotic events is rare. This is a case presentation of a 12-year-old female patient without previous events or a family history of thrombotic events who underwent a posterior spinal fusion due to severe adolescent idiopathic scoliosis. The patient developed a DVT due to an underlying Factor V Leiden mutation. The purpose of this case report is to create awareness, facilitate the diagnosis and management, and aid in future interventions and clinical outcomes.

## Linked entities

- **Diseases:** adolescent idiopathic scoliosis (MONDO:0005488)

## Full-text entities

- **Genes:** F5 (coagulation factor V) [NCBI Gene 2153] {aka FVL, PCCF, RPRGL1, THPH2, fV}
- **Diseases:** clot (MESH:D013927), adolescent idiopathic scoliosis (OMIM:181800), DVT (MESH:D020246)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11068075/full.md

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Source: https://tomesphere.com/paper/PMC11068075