# Isolated neurofibroma of the urinary bladder incidentally discovered during cystoscopy

## TL;DR

A rare case of a bladder tumor was found in a woman without a history of neurofibromatosis, highlighting the importance of biopsy and conservative treatment.

## Contribution

Reports an isolated bladder neurofibroma in a non-NF-1 patient, emphasizing diagnostic and management considerations.

## Key findings

- Isolated bladder neurofibromas are rare and often asymptomatic.
- Biopsy is essential to confirm benign nature and rule out malignancy.
- Conservative management is suitable for asymptomatic cases without NF-1.

## Abstract

Isolated neurofibromas of the urinary bladder are rare benign tumors typically associated with neurofibromatosis type 1 (NF-1). Herein highlights a bladder neurofibroma incidentally discovered during cystoscopy following midurethral sling removal in a 61-year-old woman without NF-1 sequela. Despite malignancy concerns due to smoking history, histology confirmed a benign neurofibroma. These tumors differ from NF-1-associated neurofibromas in origin and presentation; they are rare, often asymptomatic, and likely stem from somatic mutations. Conservative management is preferred, with surgical intervention indicated only for obstructive masses.

•Neurofibromas rarely present as an isolated bladder mass in patients without NF-1.•Masses should be biopsied to rule out serious malignancy.•Without other NF-1 sequelae, treatment for asymptomatic patients is conservative.

Neurofibromas rarely present as an isolated bladder mass in patients without NF-1.

Masses should be biopsied to rule out serious malignancy.

Without other NF-1 sequelae, treatment for asymptomatic patients is conservative.