# Felty Syndrome in a Patient Presenting With Bilateral Scleritis and Multiple Autoimmune Syndrome: A Case Report

**Authors:** Cameron Rattray, Sowmya Dandu, Mohammad A Hossain

PMC · DOI: 10.7759/cureus.57468 · 2024-04-02

## TL;DR

A patient with eye inflammation was found to have a rare autoimmune condition called Felty syndrome, which was successfully treated with medication.

## Contribution

This case highlights the importance of recognizing Felty syndrome in patients with multiple autoimmune symptoms.

## Key findings

- The patient had bilateral scleritis caused by multiple autoimmune syndrome type 3.
- Felty syndrome was diagnosed due to RA, splenomegaly, and neutropenia.
- Treatment with steroids and immunosuppressants improved the patient's condition.

## Abstract

Autoimmune diseases can result in additional symptoms and complications impacting various organ systems beyond the joints. These can affect the eyes, skin, respiratory, cardiac, and renal systems. Recognizing and understanding these diverse manifestations, such as the severe eye issues seen in rheumatoid arthritis (RA) and the potentially life-threatening Felty syndrome, is crucial for clinicians to promptly identify and treat these conditions effectively.

In this case presentation, we report on a patient admitted for bilateral scleritis, which was found to be secondary to multiple autoimmune syndrome type 3. During the patient's hospital stay, Felty syndrome was incidentally diagnosed due to the observed combination of RA, splenomegaly, and absolute neutropenia. Prompt recognition of this condition allowed the patient to receive appropriate care, including oral steroids, hydroxychloroquine, and methotrexate, decreasing the risk of severe complications.

## Linked entities

- **Chemicals:** hydroxychloroquine (PubChem CID 3652), methotrexate (PubChem CID 4112)
- **Diseases:** Felty syndrome (MONDO:0007603), rheumatoid arthritis (MONDO:0008383)

## Full-text entities

- **Diseases:** multiple autoimmune syndrome type 3 (OMIM:601547), Felty Syndrome (MESH:D005258), Autoimmune diseases (MESH:D001327), neutropenia (MESH:D009503), Scleritis (MESH:D015423), RA (MESH:D001172), splenomegaly (MESH:D013163)
- **Chemicals:** methotrexate (MESH:D008727), hydroxychloroquine (MESH:D006886), steroids (MESH:D013256)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11063963/full.md

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Source: https://tomesphere.com/paper/PMC11063963