# Editorial: Optimized gene-engineering and combination therapies to boost γδT cell immunotherapeutic performance

**Authors:** Marta Barisa, Daniel Abate-Daga, Jonathan Fisher

PMC · DOI: 10.3389/fimmu.2024.1414812 · 2024-04-18

## Full-text entities

- **Genes:** CEP70 (centrosomal protein 70) [NCBI Gene 80321] {aka BITE}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, Fdps (farnesyl diphosphate synthetase) [NCBI Gene 110196] {aka 6030492I17Rik, Fdpsl1, mKIAA1293}, NCR2 (natural cytotoxicity triggering receptor 2) [NCBI Gene 9436] {aka CD336, LY95, NK-p44, NKP44, dJ149M18.1}, TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}, FCGR3A (Fc gamma receptor IIIa) [NCBI Gene 2214] {aka CD16-II, CD16A, FCG3, FCGR3, FCRIIIA, FcGRIIIA}, Tnfrsf17 (tumor necrosis factor receptor superfamily, member 17) [NCBI Gene 21935] {aka BCM, BCMA, Tnfrsf13, Tnfrsf13a}, Klrk1 (killer cell lectin-like receptor subfamily K, member 1) [NCBI Gene 27007] {aka D6H12S2489E, NKG2-D, Nkg2d}, Kdr (kinase insert domain protein receptor) [NCBI Gene 16542] {aka 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR-2}, CXADRP1 (CXADR pseudogene 1) [NCBI Gene 653108] {aka CAR, CXADRP}, Cd274 (CD274 antigen) [NCBI Gene 60533] {aka A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1}, CCL2 (C-C motif chemokine ligand 2) [NCBI Gene 6347] {aka GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1}, IL17A (interleukin 17A) [NCBI Gene 3605] {aka CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17}, Ifng (interferon gamma) [NCBI Gene 15978] {aka IFN-g, If2f, Ifg}, Cd19 (CD19 antigen) [NCBI Gene 12478], FLT1 (fms related receptor tyrosine kinase 1) [NCBI Gene 2321] {aka FLT, FLT-1, VEGFR-1, VEGFR1}, Cd247 (CD247 antigen) [NCBI Gene 12503] {aka 4930549J05Rik, A430104F18Rik, Cd3, Cd3-eta, Cd3-zeta, Cd3h}, PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta) [NCBI Gene 5293] {aka APDS, IMD14, IMD14A, IMD14B, P110DELTA, PI3K}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, LAG3 (lymphocyte activating 3) [NCBI Gene 100125962] {aka CD223, LAG-3}, Il17a (interleukin 17A) [NCBI Gene 16171] {aka Ctla-8, Ctla8, IL-17, IL-17A, Il17}, Cd226 (CD226 antigen) [NCBI Gene 225825] {aka DNAM-1, DNAM1, Pta1, TLiSA1}, CD274 (CD274 molecule) [NCBI Gene 574058] {aka PDL1}, KDR (kinase insert domain receptor) [NCBI Gene 3791] {aka CD309, FLK1, VEGFR, VEGFR2}, Il2 (interleukin 2) [NCBI Gene 16183] {aka Il-2}
- **Diseases:** acute myeloid leukaemia (MESH:D054218), multiple myeloma (MESH:D009101), cytotoxicity (MESH:D064420), mesothelioma (MESH:D008654), non-small cell lung carcinoma (MESH:D002289), leukaemia (MESH:D015458), breast cancer (MESH:D001943), cancer (MESH:D009369), AML (MESH:D015470), B cell malignancies (MESH:D016393), GvHD (MESH:D006086)
- **Chemicals:** lipid (MESH:D008055), RPMI1640 (-), IPP (MESH:C004809), cholesterol (MESH:D002784), zoledronic acid (MESH:D000077211), sulfatide (MESH:D013433)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** THP-1 — Homo sapiens (Human), Childhood acute monocytic leukemia, Cancer cell line (CVCL_0006), NSG — Homo sapiens (Human), Glioblastoma, Cancer cell line (CVCL_B7HV), CAR-T — Mus musculus (Mouse), Transformed cell line (CVCL_WN86)

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Source: https://tomesphere.com/paper/PMC11063349