Correlation of age with the size of subcortical nuclei of the brain and its implication in degenerative disease: A magnetic resonance imaging study
Aditij Dhamija, Lydia S. Andrade, Prakashini K., Chandni Gupta, Vidya CS JSSMC00341, Chandni Gupta
TL;DR
This study uses MRI scans to show how brain structures change with age and may help detect early signs of degenerative diseases.
Contribution
The study identifies gender-specific correlations between age and subcortical brain nuclei sizes, offering potential clinical indicators for degenerative diseases.
Findings
Gender differences were found in the axial diameters of the caudate nucleus, putamen, and globus pallidus.
Caudate nucleus transverse diameter showed a moderate negative correlation with age in males.
Globus pallidus transverse diameter showed a stronger positive correlation with age in males compared to females.
Abstract
Background: Aging is a non-modifiable risk factor for neurodegenerative disease. It is well established that the brain undergoes physiological atrophy with age. So, this study was conducted to analyse the correlation between the age of the person and the size of the various subcortical nuclei of the brain and whether these measurements can serve as a useful indicator for physiological atrophy leading to degenerative disease in clinical practice. Methods: A total of 600 MRI scans from healthy individuals were examined and the measurements of subcortical nuclei were taken and subsequently analysed. Results: A statistically significant difference between the genders was observed in the sizes of the axial diameters of caudate nucleus, putamen and globus pallidus. Caudate nucleus transverse diameter showed a moderate negative correlation with age in males. Globus pallidus axial diameter…
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Taxonomy
TopicsNeurological disorders and treatments · Neurological and metabolic disorders · Advanced Neuroimaging Techniques and Applications