# Editorial: Investigation of the biological properties of natural products using experimental approaches and in silico methods

**Authors:** Suraj N. Mali, Cleydson Breno Rodrigues dos Santos, Joaquín Campos Rosa, Jorddy Neves Cruz

PMC · DOI: 10.3389/fchem.2024.1406883 · 2024-04-17

## Full-text entities

- **Genes:** SIRT1 (sirtuin 1) [NCBI Gene 23411] {aka SIR2, SIR2L1, SIR2alpha}, BAX (BCL2 associated X, apoptosis regulator) [NCBI Gene 581] {aka BCL2L4}, BCL2 (BCL2 apoptosis regulator) [NCBI Gene 596] {aka Bcl-2, PPP1R50}, Mpro [NCBI Gene 8673700], CASP3 (caspase 3) [NCBI Gene 836] {aka CPP32, CPP32B, SCA-1}
- **Diseases:** hypertension (MESH:D006973), malaria (MESH:D008288), death (MESH:D003643), cancer (MESH:D009369), cytotoxic (MESH:D064420)
- **Chemicals:** isoeleutherin (MESH:C529519), DA (MESH:C012301), sodium butyrate (MESH:D020148), flavonoids (MESH:D005419), essential oil (MESH:D009822), 1d-02 (-), proanthocyanidins (MESH:D044945), beta-sitosterol (MESH:C025473), saponins (MESH:D012503), P (MESH:D010758), quercetin (MESH:D011794), Ca (MESH:D002118)
- **Species:** Ficus racemosa (cluster fig, species) [taxon 100569], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Ciona robusta (species) [taxon 1774208], Bacillus sp. (in: firmicutes) (species) [taxon 1409], Homo sapiens (human, species) [taxon 9606], Trillium govanianum (species) [taxon 82485], Plasmodium falciparum (malaria parasite P. falciparum, species) [taxon 5833]
- **Cell lines:** HT-29 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0320), U2OS — Homo sapiens (Human), Osteosarcoma, Cancer cell line (CVCL_0042), A-549 — Homo sapiens (Human), Lung adenocarcinoma, Cancer cell line (CVCL_0023), SW-620 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0547), HepG2 — Homo sapiens (Human), Hepatoblastoma, Cancer cell line (CVCL_0027)

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Source: https://tomesphere.com/paper/PMC11061476