# Harnessing naturally occurring mutations for T-cell therapy: a potential new avenue to enhance treatment efficacy

**Authors:** Michael Hiltensperger, Jürgen Ruland, Kilian Schober

PMC · DOI: 10.1038/s41392-024-01835-y · 2024-04-30

## Full-text entities

- **Genes:** KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, ITK (IL2 inducible T cell kinase) [NCBI Gene 3702] {aka EMT, LPFS1, LYK, PSCTK2}, CD19 (CD19 molecule) [NCBI Gene 930] {aka B4, CVID3}, JUND (JunD proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 3727] {aka AP-1}, PDCD1 (programmed cell death 1) [NCBI Gene 5133] {aka ADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2}, IL2 (interleukin 2) [NCBI Gene 3558] {aka IL-2, TCGF, lymphokine}, SYK (spleen associated tyrosine kinase) [NCBI Gene 6850] {aka IMD82, p72-Syk}, BCL10 (BCL10 immune signaling adaptor) [NCBI Gene 8915] {aka CARMEN, CIPER, CLAP, IMD37, c-E10, mE10}, NR1I3 (nuclear receptor subfamily 1 group I member 3) [NCBI Gene 9970] {aka CAR, CAR1, MB67}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, CARD11 (caspase recruitment domain family member 11) [NCBI Gene 84433] {aka BENTA, BIMP3, CARMA1, IMD11, IMD11A, PPBL}, PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3) [NCBI Gene 8503] {aka p55, p55-GAMMA, p55PIK}, TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}, CD28 (CD28 molecule) [NCBI Gene 940] {aka IMD123, Tp44}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, MCAM (melanoma cell adhesion molecule) [NCBI Gene 4162] {aka CD146, HEMCAM, METCAM, MUC18, MelCAM}, MALT1 (MALT1 paracaspase) [NCBI Gene 10892] {aka IMD12, MLT, MLT1, PCASP1}, TNFRSF9 (TNF receptor superfamily member 9) [NCBI Gene 3604] {aka 4-1BB, CD137, CDw137, ILA, IMD109}
- **Diseases:** acute lymphoblastic leukemia (MESH:D054198), cancer (MESH:D009369), melanoma (MESH:D008545), lymphomas (MESH:D008223), CRS (MESH:D000080424), gastric cancer (MESH:D013274), chronic lymphocytic leukemia (MESH:D015451), cutaneous T cell lymphoma (MESH:D016410), T cell lymphoma (MESH:D016399)
- **Chemicals:** tyrosine (MESH:D014443)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** G12D
- **Cell lines:** K562 — Homo sapiens (Human), Blast phase chronic myelogenous leukemia, BCR-ABL1 positive, Cancer cell line (CVCL_0004), hCD19 — Cricetulus griseus (Chinese hamster), Spontaneously immortalized cell line (CVCL_9Y69), B16 — Mus musculus (Mouse), Hybridoma (CVCL_U043), Nalm6 — Homo sapiens (Human), Adult B acute lymphoblastic leukemia, Cancer cell line (CVCL_0092), Jurkat — Homo sapiens (Human), Childhood T acute lymphoblastic leukemia, Cancer cell line (CVCL_0065)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11061186/full.md

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Source: https://tomesphere.com/paper/PMC11061186