# Remission of Clozapine-Induced Hepatotoxicity Following a Switch to Olanzapine Augmented with Haloperidol: A Case Report and Literature Review

## TL;DR

A patient with liver toxicity from clozapine recovered after switching to olanzapine and haloperidol, without relapse of mental illness or liver issues.

## Contribution

This case report provides a successful treatment strategy for managing psychiatric symptoms after clozapine-induced hepatotoxicity.

## Key findings

- Clozapine-induced hepatotoxicity resolved after drug cessation and conservative management.
- Psychiatric symptoms were effectively managed with olanzapine and haloperidol without liver toxicity recurrence.
- The combination therapy prevented psychosis relapse and liver complications.

## Abstract

Clozapine is an effective medication for treatment-resistant schizophrenia, and it has been associated with well-documented side effects that limit its use. Clozapine-induced hepatotoxicity is a less-known complication of clozapine therapy. The literature is unclear about the psychopharmacologic options available following clozapine cessation on account of liver toxicity. We present a patient with clinical symptomatology in keeping with clozapine-induced hepatotoxicity who achieved full recovery following clozapine cessation and conservative medical management. Her psychiatric symptomatology was successfully managed with oral olanzapine augmented with haloperidol without recurrence of psychosis or liver toxicity.