# Multiple checkpoints ensure ribosomes have the correct end

## TL;DR

This study shows that cells use multiple checkpoints to ensure ribosomes have the correct 3’ end for proper translation.

## Contribution

The discovery of multiple checkpoints ensuring correct ribosome 3’ end formation is novel.

## Key findings

- Multiple checkpoints ensure only ribosomes with the correct 3’ end participate in translation.
- The endoribonuclease Nob1 forms the 3’ end of 18S ribosomal RNA.

## Abstract

The 3′ end of the 18S ribosomal RNA is formed by the endoribonuclease Nob1. How cells ensure the accuracy of the 3′ end has remained a mystery. A new study in PLOS Biology revealed that there are multiple checkpoints to ensure that only ribosomes containing the correct 3′ end participate in translation.

The 3’ end of 18S ribosomal RNA is formed by the endoribonuclease Nob1, but how cells ensure the accuracy of the 3’ end has been a mystery. A new study in PLOS Biology has revealed multiple checkpoints that ensure only ribosomes containing the correct 3’ end participate in translation.