# Exploring the Relationship of SARS-CoV-2 and Uric Acid Levels With a Focus on Gout Patients: A Scoping Review

## TL;DR

This paper explores how SARS-CoV-2 and uric acid levels relate to gout, focusing on how gout might influence or be influenced by the virus.

## Contribution

The novelty lies in systematically reviewing the interplay between SARS-CoV-2 infection, uric acid levels, and gout.

## Key findings

- Gout is linked to systemic inflammation and comorbidities like T2DM and cardiovascular disease.
- Uric acid levels may influence SARS-CoV-2 infection outcomes in gout patients.
- Early diagnosis and treatment of gout are crucial to prevent complications.

## Abstract

Rheumatic diseases are a group of conditions including arthritis and various other conditions that can lead to chronic inflammation within the musculoskeletal system, which can have negative effects on soft tissues, bones, muscles, joints, and connective tissue. One form of arthritis is gout, which is an inflammatory condition in which urate acid crystals build up in joints. Gout is associated with joint swelling, pain, redness, and joint mobility issues. Early diagnosis and treatment are essential to prevent joint degradation and other adverse complications. The condition has been shown to increase the incidence of diseases outside the musculoskeletal system, including the renal and cardiovascular systems. Comorbid conditions associated with gout include but are not limited to type 2 diabetes mellitus (T2DM), hypertension, hyperlipidemia, chronic kidney disease, cardiovascular disease, and heart failure. This systematic review aims to provide insight into the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, uric acid levels, and gout.