Systemic amyloid A amyloidosis of the bladder after transurethral resection of urothelial carcinoma

TL;DR

A patient with bladder cancer was found to have amyloid A amyloidosis in the bladder and possibly the heart, highlighting the importance of biopsy in diagnosing systemic disease.

Contribution

This case report highlights the detection of systemic amyloid A amyloidosis through bladder tumor biopsy in a patient with urothelial carcinoma.

Findings

Bladder tumor biopsy revealed amyloid A amyloidosis.

The patient's cardiac disease may be linked to systemic amyloid A amyloidosis.

Bladder pathology can aid in diagnosing systemic amyloid A amyloidosis.

Abstract

Amyloid A amyloidosis of the bladder is not a major disease. We report a patient with systemic amyloid A amyloidosis of the bladder after transurethral resection of urothelial carcinoma.

An 87‐year‐old Japanese man had bladder carcinoma. He was followed up regularly with cystoscopy. Cystoscopy revealed multiple polypoid tumors 6 months after the first transurethral resection of urothelial carcinoma. Pathologic specimens contained the amyloid A component. He had hypertrophic cardiomyopathy, valvular disorders, and arrhythmias. His cardiac disease may have resulted from amyloid A amyloidosis. We speculated the patient had systemic amyloid A amyloidosis of the heart and bladder.

We determined the type of amyloidosis via a biopsy of the bladder tumors. Our patient had cardiac disease. Therefore, systemic amyloid A amyloidosis could have caused his cardiac disease. The pathologic findings of bladder tumors can contribute to detecting systemic amyloid A amyloidosis.

Figures