A Rare Presentation of Guillain-Barré Syndrome With Associated Horner Syndrome: A Case Report

TL;DR

A rare case of Guillain-Barré syndrome is reported with unusual Horner syndrome, highlighting the importance of accurate diagnosis.

Contribution

This case report adds to the limited literature on GBS presenting with Horner syndrome.

Findings

GBS can present with acute flaccid paraparesis and unilateral Horner syndrome.

Diagnosing GBS with atypical symptoms requires heightened clinical awareness.

Abstract

Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy involving the peripheral nervous system. Autonomic dysfunctions are well-known complications of GBS and are major contributors to mortality. Autonomic dysfunctions are classically described during the acute phase of illness. In the literature, Horner syndrome as a manifestation of GBS has been reported in very few cases. Here, we describe a case of GBS with an acute presentation of flaccid paraparesis associated with unilateral Horner syndrome. Detecting the cause of acute flaccid paraparesis with unilateral Horner syndrome poses a diagnostic challenge, making it crucial for clinicians to maintain a heightened awareness for distinguishing between GBS and its variants, as well as other potential mimics.

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