Synthesis, Cytotoxicity, and Photophysical Investigations of 2-Amino-4,6-diphenylnicotinonitriles: An Experimental and Theoretical Study
Alwah R. Al-Ghamdi, Shofiur Rahman, Reem I. Al-Wabli, Maha S. Al-Mutairi, A. F. M. Motiur Rahman
TL;DR
This paper studies new compounds that show strong cancer-fighting potential and unique light-emitting properties, which could be useful for sensors and cancer treatments.
Contribution
The study introduces novel 2-amino-4,6-diphenylnicotinonitriles with high cytotoxicity and solvent-dependent fluorescence properties.
Findings
Compound 3 shows higher cytotoxicity than Doxorubicin against breast cancer cells.
Fluorescence emission of APNs shifts with solvent, indicating environmental sensitivity.
TD-DFT analysis reveals electronic properties like HOMO-LUMO gaps and dipole moments.
Abstract
In this study, we present a comprehensive investigation of 2-amino-4,6-diphenylnicotinonitriles (APNs, 1–6), including their synthesis, cytotoxicity against breast cancer cell lines, and photophysical properties. Compound 3 demonstrates exceptional cytotoxicity, surpassing the potency of Doxorubicin. The fluorescence spectra of the synthesized 1–6 in different solvents reveal solvent-dependent shifts in the emission maximum values, highlighting the influence of the solvent environment on their fluorescence properties. A quantum chemical TD-DFT analysis provides insights into the electronic structure and fluorescence behavior of 1–6, elucidating HOMO-LUMO energy gaps, electronegativity values, and dipole moments, contributing to a deeper understanding of their electronic properties and potential reactivity. These findings provide valuable knowledge for the development of APNs (1–6) as…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsSynthesis and biological activity · Multicomponent Synthesis of Heterocycles · Synthesis and Characterization of Heterocyclic Compounds