# Cutaneous Calcified Mass of Foot in Pseudohypoparathyoidism: Case Report

**Authors:** Sang Heon Lee, Sung Hwan Kim, Seung Jin Choi, Young Koo Lee

PMC · DOI: 10.3390/medicina60040595 · Medicina · 2024-04-04

## TL;DR

A 15-year-old girl with a history of pseudohypoparathyroidism had a painful calcified foot mass, diagnosed through medical history, lab tests, and imaging, leading to successful surgical removal.

## Contribution

This case report highlights a rare manifestation of osteoma cutis in a patient with pseudohypoparathyroidism and Albright’s hereditary osteodystrophy.

## Key findings

- The patient’s calcified foot mass was diagnosed as osteoma cutis based on clinical and laboratory findings.
- Surgical excision provided complete pain relief, confirming the diagnosis.
- The case underscores the importance of considering rare metabolic conditions in diagnosing calcified masses.

## Abstract

Soft tissue calcifications frequently appear on imaging studies, representing a prevalent but non-specific discovery, varying from a local reaction without clear cause to suggesting an underlying systemic condition. Because calcifications like these can arise from various causes, an accurate differential diagnosis is crucial. Differential diagnosis entails a methodical assessment of the patient, encompassing clinical presentation, medical history, radiological and pathological findings, and other pertinent factors. Through scrutiny of the patient’s medical and trauma history, we can refine potential causes of calcification to vascular, metabolic, autoimmune, neoplastic, or traumatic origins. Furthermore, routine laboratory assessments, including serum levels of calcium, phosphorus, ionized calcium, vitamin D metabolites, and parathyroid hormone (PTH), aid in identifying metabolic etiologies. We describe a rare occurrence of osteoma cutis in a 15-year-old female patient with a history of pseudohypoparathyroidism (PHP) and Albright’s hereditary osteodystrophy (AHO). The patient presented with a painful mass on the lateral side of her left foot. The diagnosis was based on medical history, laboratory tests, and imaging, leading to an excisional biopsy and complete pain relief post-surgery. Understanding such rare occurrences and related conditions is crucial for accurate diagnosis and management.

## Linked entities

- **Diseases:** pseudohypoparathyroidism (MONDO:0019992)

## Full-text entities

- **Genes:** PTH (parathyroid hormone) [NCBI Gene 5741] {aka FIH1, PTH1}
- **Diseases:** osteoma cutis (MESH:C562735), calcification (MESH:D002114), pain (MESH:D010146), Calcified (MESH:D018333), AHO (MESH:D011547), trauma (MESH:D014947)
- **Chemicals:** phosphorus (MESH:D010758), calcium (MESH:D002118), vitamin D (MESH:D014807)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11052086/full.md

## References

35 references — full list in the complete paper: https://tomesphere.com/paper/PMC11052086/full.md

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Source: https://tomesphere.com/paper/PMC11052086