High Starch Induces Hematological Variations, Metabolic Changes, Oxidative Stress, Inflammatory Responses, and Histopathological Lesions in Largemouth Bass (Micropterus salmoides)
Yuanyuan Xie, Xianping Shao, Penghui Zhang, Hao Zhang, Jiaxing Yu, Xinfeng Yao, Yifan Fu, Jiao Wei, Chenglong Wu
TL;DR
Feeding largemouth bass a high-starch diet causes metabolic issues, oxidative stress, inflammation, and liver damage.
Contribution
This study reveals new insights into how high starch diets affect fish metabolism, inflammation, and liver health through specific molecular pathways.
Findings
High starch diets increase lipid accumulation and disrupt glucose and cholesterol metabolism in largemouth bass.
High starch activates the NLRP3 inflammasome, leading to increased inflammatory responses and oxidative stress.
Histopathological changes like lipid droplets and vacuolization are observed in the livers of fish fed high starch.
Abstract
This study evaluated effects of high starch (20%) on hematological variations, glucose and lipid metabolism, antioxidant ability, inflammatory responses, and histopathological lesions in largemouth bass. Results showed hepatic crude lipid and triacylglycerol (TAG) contents were notably increased in fish fed high starch. High starch could increase counts of neutrophils, lymphocytes, monocytes, eosinophils, and basophils and serum contents of TAG, TBA, BUN, and LEP (p < 0.05). There were increasing trends in levels of GLUT2, glycolysis, gluconeogenesis, and LDH in fish fed high starch through the AKT/PI3K signal pathway. Meanwhile, high starch not only triggered TAG and cholesterol synthesis, but mediated cholesterol accumulation by reducing ABCG5, ABCG8, and NPC1L1. Significant increases in lipid droplets and vacuolization were also shown in hepatocytes of D3–D7 groups fed high starch.…
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Taxonomy
TopicsHistorical Art and Architecture Studies · Medicine and Dermatology Studies History · History of Education in Spain