Primary small lymphocytic lymphoma of the breast: a rare presentation of non-Hodgkin’s lymphoma

TL;DR

A rare case of primary small lymphocytic lymphoma in the breast is reported in a 65-year-old woman with no prior lymphoma history.

Contribution

This case report highlights the rare occurrence of primary small lymphocytic lymphoma in the breast.

Findings

The patient had a breast nodule diagnosed as low-grade B-cell lymphoma via biopsy.

Final pathology confirmed primary low-grade B-cell lymphocytic lymphoma of the breast.

Follow-up PET scan showed no abnormal glucose metabolism or lymph node involvement.

Abstract

Primary Small Lymphocytic Lymphoma of the breast is a rare presentation of Non-Hodgkin’s lymphoma. In this report, we present the case of primary small lymphocytic lymphoma of the breast in a 65-year-old female who presented with an abnormal breast ultrasound significant for a nodule of the right breast consistent with BI-RADS 4, indicating follow-up with ultrasound-guided biopsy for further diagnostic evaluation. The patient had no prior history of extramammary lymphoma or widespread disease. A sample of the breast mass was obtained via ultrasound-guided core needle biopsy and the pathology report revealed low-grade B-cell Lymphoma. After discussion with medical oncology and the explanation of risks, benefits and alternatives to surgery, a lumpectomy was performed, and the final pathology report of the mass revealed primary low-grade B-cell lymphocytic lymphoma of the breast. On follow up, the PET scan was unremarkable and showed no evidence of abnormal glucose metabolism or adenopathy.

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