# Bibliometric analysis of cerebral organoids and diseases in the last 10 years

## TL;DR

This paper reviews 10 years of research on cerebral organoids and their use in studying brain diseases, highlighting trends and future directions.

## Contribution

The study provides a comprehensive bibliometric analysis of cerebral organoid research in diseases from 2013 to 2022.

## Key findings

- The USA, China, and Germany led in cerebral organoid research publications.
- Stem cell-derived organoids are a major focus for modeling and treating neurological diseases.
- Cerebral organoids are increasingly used for drug screening in neurological disorders.

## Abstract

Cerebral organoids have emerged as a powerful tool for mirroring the brain developmental processes and replicating its unique physiology. This bibliometric analysis aims to delineate the burgeoning trends in the application of cerebral organoids in disease research and offer insights for future investigations. We screened all relevant literature from the Web of Science on cerebral organoids in disease research during the period 2013–2022 and analyzed the research trends in the field using VOSviewer, CiteSpace, and Scimago Graphica software. According to the search strategy, 592 articles were screened out. The United States of America (USA) was the most productive, followed by China and Germany. The top nine institutions in terms of the number of publications include Canada and the United States, with the University of California, San Diego (USA), having the highest number of publications. The International Journal of Molecular Sciences was the most productive journal. Knoblich, Juergen A., and Lancaster, Madeline A. published the highest number of articles. Keyword cluster analysis showed that current research trends focused more on induced pluripotent stem cells to construct organoid models of cerebral diseases and the exploration of their mechanisms and therapeutic modalities. This study provides a comprehensive summary and analysis of global research trends in the field of cerebral organoids in diseases. In the past decade, the number of high‐quality papers in this field has increased significantly, and cerebral organoids provide hope for simulating nervous system diseases (such as Alzheimer's disease).

This review explores the progress of research on cerebral organoids in the last 10 years, mainly using bibliometric methods. The Web of Science (WOS) database was searched for literature related to cerebral organoids and diseases published from 2013 to 2023 using the keywords “cerebral organoids” and “diseases.” Research trends in the field were analyzed using VOSviewer, CiteSpace, and Scimago Graphica software. The methodology was explored to derive the current research hotspots in the field of cerebral organoids and future directions. The current research trend focuses on the use of stem cells to construct brain organoids, and then delves into the mechanisms and treatments of neurological diseases. In addition to this, cerebral organoids are also used for the screening of drugs for neurological diseases, and this application will accelerate the development of drugs for neurological diseases. This article analyzes the last 10 years of research on cerebral organoids and diseases, which will help researchers understand the current status of the field, anchor research directions, and provide a reference base for advancing the field.