# A case of phyllodes tumor with rapid growth during pregnancy and lactation period: a case report

## TL;DR

A 39-year-old woman developed a rapidly growing phyllodes tumor during pregnancy and lactation, which was later diagnosed as benign.

## Contribution

This case highlights the rare occurrence of phyllodes tumor growth during pregnancy and lactation.

## Key findings

- The tumor increased in size during pregnancy and lactation, reaching 85 mm in diameter.
- The tumor contained a milk-like substance, which may have contributed to its rapid growth.
- Histological analysis confirmed a benign phyllodes tumor with degeneration.

## Abstract

The age of onset of the phyllodes tumor is generally in the late 40 s, and diagnosis and treatment during pregnancy and lactation are rare. We herein present a case of a phyllodes tumor that rapidly increased in size during the pregnancy and lactation period.

A 39-year-old woman was referred to our hospital with a mass in the right breast that increased in size during the pregnancy and lactation period. On ultrasound (5 week postpartum), a well-defined lobulated mass with internal septations and fluid retention was observed. Magnetic resonance imaging of the breast at 8 week postpartum revealed a 70-mm-sized smooth-margin mass with multilocular cystic components. Marked proliferation of stromal cells with high cell density was observed in a biopsy specimen taken at the previous hospital. We diagnosed the mass as a phyllodes tumor of borderline malignancy and excised it at 13 week postpartum. The excised tumor was 85 mm in diameter and its interior was filled with a milk-like substance. Histologically, there was only a mild increase in stromal cell density but fibrosis with associated degeneration was prominent. The final diagnosis was benign phyllodes tumor with degeneration.

We report a case of a phyllodes tumor that rapidly increased in size during pregnancy and the lactation period. The accumulation of a milk-like substance was thought to be responsible for the rapid growth of the tumor.