# CRISPR/Cas9-mediated knock-in cells of the late-onset Alzheimer’s disease-risk variant, SHARPIN G186R, reveal reduced NF-κB pathway and accelerated Aβ secretion

**Authors:** Yuya Asanomi, Tetsuaki Kimura, Nobuyoshi Shimoda, Daichi Shigemizu, Shumpei Niida, Kouichi Ozaki

PMC · DOI: 10.1038/s10038-024-01224-x · 2024-02-13

## Full-text entities

- **Genes:** APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, SHARPIN (SHANK associated RH domain interactor) [NCBI Gene 81858] {aka AIFID, SIPL1}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}
- **Diseases:** Alzheimer's disease (MESH:D000544)
- **Mutations:** G186R

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11043039/full.md

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Source: https://tomesphere.com/paper/PMC11043039