# A fractional perspective on the transmission dynamics of a parasitic infection, considering the impact of both strong and weak immunity

**Authors:** Tao-Qian Tang, Rashid Jan, Zahir Shah, Narcisa Vrinceanu, Ciprian Tanasescu, Asif Jan, Maria Stefania Latrofa, Maria Stefania Latrofa, Maria Stefania Latrofa

PMC · DOI: 10.1371/journal.pone.0297967 · PLOS ONE · 2024-04-24

## TL;DR

This paper studies the spread of cryptosporidiosis using a fractional model that considers strong and weak immunity to understand disease dynamics and control.

## Contribution

The novelty lies in applying a fractional framework with strong and weak immunity to model cryptosporidiosis transmission.

## Key findings

- The disease-free steady-state is locally asymptotically stable when R0 < 1.
- The model's existence and uniqueness are proven using Schaefer and Banach fixed point theorems.
- Numerical techniques highlight the impact of key determinants on infection dynamics.

## Abstract

Infectious disease cryptosporidiosis is caused by the cryptosporidium parasite, a type of parasitic organism. It is spread through the ingestion of contaminated water, food, or fecal matter from infected animals or humans. The control becomes difficult because the parasite may remain in the environment for a long period. In this work, we constructed an epidemic model for the infection of cryptosporidiosis in a fractional framework with strong and weak immunity concepts. In our analysis, we utilize the well-known next-generation matrix technique to evaluate the reproduction number of the recommended model, indicated by R0. As R0<1, our results show that the disease-free steady-state is locally asymptotically stable; in other cases, it becomes unstable. Our emphasis is on the dynamical behavior and the qualitative analysis of cryptosporidiosis. Moreover, the fixed point theorem of Schaefer and Banach has been utilized to investigate the existence and uniqueness of the solution. We identify suitable conditions for the Ulam-Hyers stability of the proposed model of the parasitic infection. The impact of the determinants on the sickness caused by cryptosporidiosis is highlighted by the examination of the solution pathways using a novel numerical technique. Numerical investigation is conducted on the solution pathways of the system while varying various input factors. Policymakers and health officials are informed of the crucial factors pertaining to the infection system to aid in its control.

## Linked entities

- **Diseases:** cryptosporidiosis (MONDO:0015474)

## Full-text entities

- **Diseases:** Infectious disease (MESH:D003141), cryptosporidiosis (MESH:D003457), parasitic infection (MESH:D010272), infection (MESH:D007239)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

36 references — full list in the complete paper: https://tomesphere.com/paper/PMC11042725/full.md

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Source: https://tomesphere.com/paper/PMC11042725