# Primary Hyperaldosteronism in a Normotensive Patient: A Case Report

**Authors:** Amir Hossein Ghanooni, Mitra KazemiJahromi, Farhad Hosseinpanah

PMC · DOI: 10.5812/ijem-138703 · International Journal of Endocrinology and Metabolism · 2023-12-13

## TL;DR

A normotensive woman with low potassium and high aldosterone was diagnosed with an adrenal tumor, showing that primary hyperaldosteronism can occur without high blood pressure.

## Contribution

Highlights the importance of considering primary hyperaldosteronism in normotensive patients with severe hypokalemia.

## Key findings

- A normotensive patient presented with hypokalemia, high aldosterone, and suppressed renin.
- CT scan revealed an adrenal mass, confirmed as an adrenal adenoma after surgery.
- The case suggests PA can manifest without hypertension.

## Abstract

Primary aldosteronism (PA) is a clinical syndrome characterized by hypertension, suppressed plasma renin activity (PRA), elevated plasma aldosterone concentration (PAC), and spontaneous hypokalemia.

We present a 37-year-old normotensive female with hypokalemia, high plasma aldosterone level, and suppressed renin. The patient was treated with eplerenone and potassium chloride supplement. Further investigation with a computed tomography (CT) scan revealed a mass in the left adrenal. Laparoscopic adrenalectomy led to the diagnosis of adrenal adenoma.

Primary aldosteronism should be among the differential diagnoses in normotensive patients presenting with severe hypokalemia.

## Linked entities

- **Chemicals:** eplerenone (PubChem CID 443872), potassium chloride (PubChem CID 4873)
- **Diseases:** Primary aldosteronism (MONDO:0001422), hypokalemia (MONDO:0003019)

## Full-text entities

- **Genes:** REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}
- **Diseases:** PA (OMIM:617027), Primary Hyperaldosteronism (MESH:D006929), hypertension (MESH:D006973), adrenal adenoma (MESH:D018246), hypokalemia (MESH:D007008)
- **Chemicals:** eplerenone (MESH:D000077545), potassium chloride (MESH:D011189), aldosterone (MESH:D000450)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC11041995/full.md

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Source: https://tomesphere.com/paper/PMC11041995