# Evaluation of Steroid Pulse Therapy Responsiveness in Myelin-Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis

## TL;DR

This study explores which factors predict how well patients with a specific type of optic neuritis respond to steroid treatment.

## Contribution

The study identifies that initial visual field impairment may predict the need for additional treatment in steroid pulse therapy for optic neuritis.

## Key findings

- Initial best corrected visual acuity did not correlate with post-treatment outcomes.
- Initial mean deviation values correlated with post-treatment visual field results.
- Factors like age, gender, and imaging findings did not influence treatment outcomes.

## Abstract

Purpose: Myelin-oligodendrocyte glycoprotein antibody-positive optic neuritis (MOGON) is usually responsive to the steroid, but, for some patients, steroid pulse therapy alone may be inadequate. This study aimed to investigate the factors predicting the response to steroid pulse therapy in MOGON.

Methods: This study included 17 patients (24 eyes) with MOGON, who received single steroid pulse therapy as initial treatment. Best corrected visual acuity (BCVA) and mean deviation (MD) values after treatment were examined concerning findings at onset.

Results: No correlation was found between BCVA at onset and after treatment, but a correlation was observed between MD values at onset and after treatment (correlation coefficient 0.48, p=0.01, Spearman's rank correlation coefficient). Age, gender, duration from onset to treatment, magnetic resonance imaging findings, and optical coherence tomography findings did not affect visual function after treatment.

Conclusions: Severe visual field impairment at onset may indicate that additional treatment may be necessary.