# Pharmacologic Anisocoria With Azelastine: The Importance of a Good Anamnesis

**Authors:** Margarida Ribeiro, Rita Teixeira-Martins, Jorge Meira

PMC · DOI: 10.7759/cureus.56649 · Cureus · 2024-03-21

## TL;DR

A patient presented with a dilated pupil caused by azelastine, highlighting the importance of a detailed medical history in avoiding unnecessary tests.

## Contribution

This case emphasizes the role of thorough anamnesis in diagnosing azelastine-induced anisocoria.

## Key findings

- Unilateral mydriasis was identified as a rare side effect of azelastine.
- A detailed patient history helped avoid unnecessary diagnostic procedures.
- The case underscores the importance of considering medication history in anisocoria evaluation.

## Abstract

Unilateral pharmacologic mydriasis is one of the differential diagnoses of anisocoria. This is a clinical case of a 37-year-old male patient admitted to the ophthalmology emergency department with unilateral mydriasis, an infrequent side effect of the antihistaminic drug azelastine. A comprehensive medical history including ocular medication was essential to avoid the need for additional tests and to exclude life-threatening conditions responsible for a similar presentation.

## Linked entities

- **Chemicals:** azelastine (PubChem CID 2267)

## Full-text entities

- **Diseases:** mydriasis (MESH:D015878), Anisocoria (MESH:D015875)
- **Chemicals:** Azelastine (MESH:C020976)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC11032175/full.md

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Source: https://tomesphere.com/paper/PMC11032175